Homozygous familial hypercholesterolemia


HoFH (homozygous familial hypercholesterolemia) is a very rare genetic disorder with life-threatening consequences for those affected. It is the most severe form of familial hypercholesterolemia, which is characterised by extremely high LDL (low-density lipoprotein) cholesterol levels. 

The long-term exposure to significant elevated LDL-C levels in patients with HoFH can lead to premature atherosclerosis and increased risk of cardiovascular events such as acute coronary syndrome, heart attack, and stroke.

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    Cause & Symptoms
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    Diagnosis & Therapy
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    Everyday life

Everyday life

Being diagnosed with homozygous familial hypercholesterolemia presents the patients and their relatives with new challenges. The aim is to lower the risk of suffering from cardiovascular diseases by means of various measures, which include regular medical treatment and check-ups at a specialised centre. Other important measures that need to be carried out by patients and their family every day by themselves after being instructed accordingly include: optimising their diet, doing appropriate and regular exercise and avoiding risks.

Information helps

Knowing about the disease, its effects and consequences helps to adopt a healthy lifestyle. Exchanging information with other patients and their families, such as through patient organisations, makes it easier to cope with daily life and to overcome problems.

For more information, go to the following website:

FHcolAustria