At AOP Orphan, we have been contributing to research on myeloproliferative neoplasms (MPNs) for many years. On September 9th – the 9th Annual MPN Awareness Day – we especially want to help raising awareness of MPNs, since we believe that informing, connecting and advocating for those who are affected and involved is crucial for the well-being of patients. We will extend these efforts over the following months and bring into focus relevant information, advice and insights on all our communication platforms.
“MPNs is a chronic haematological disease group caused by a stem-cell disorder. William Dameshek, an US haematologist, described this group of diseases for the first time approximately sixty years ago. He was looking at common symptoms and phenomena e.g. thromboses, constitutional symptoms, but also the unifying hyperproliferation of the bone marrow combined with splenomegaly and an increased number of thrombosis and bleeding events. 2016 WHO has renewed the definition of MPNs."
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Prof. Dr. Martin Griesshammer
The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms includes the following myeloproliferative neoplasms (MPNs):
Source: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Daniel A. Arber, Attilio Orazi, Robert Hasserjian, Jürgen Thiele, Michael J. Borowitz, Michelle M. Le Beau, Clara D. Bloomfield, Mario Cazzola and James W. Vardiman. Blood 2016 127:2391-2405.
"Under the umbrella of myeloproliferative neoplasms (MPNs) there are diﬀerent diseases that belong to the family of malignancies. MPNs are completely diﬀerent from solid cancers since MPNs are chronic diseases mostly. MPNs develop in the bone marrow of the patients and produce too many blood cells. According to the category of blood cells that are predominant, we can classify these diseases in diﬀerent categories.
One is polycythaemia vera, there is mostly an increase of red blood cells but sometimes also along with too many white cells and platelets.
Then, if only platelets are increased, it’s usually essential thrombocythemia.
And you have the third one which is primary myelofibrosis that is a kind of a more heterogeneous disease group of patients with diﬀerent aspects.
In general it’s always an overproduction of blood cells. “
Click on the arrow icon below to find out more about Polycythaemia Vera and Essential Thrombocythemia, its causes, symptoms, and diagnosis.