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What are MPNs? 

  • MPNs stands for myeloproliferative neoplasms
  • MPNs are a group of rare disorders of the bone marrow
  • MPNs are blood cancers that occur when the body produces too many red or/and white blood cells, or/and platelets.

     
Prof. Dr. Martin Griesshammer Director, Department of Hematology, Oncology, Hemostaseology and Palliative Medicine, Mühlenkreis clinics

“MPNs is a chronic haematological disease group caused by a stem-cell disorder. William Dameshek, an US haematologist, described this group of diseases for the first time approximately sixty years ago. He was looking at common symptoms and phenomena e.g. thromboses, constitutional symptoms, but also the unifying hyperproliferation of the bone marrow combined with splenomegaly and an increased number of thrombosis and bleeding events. 2016 WHO has renewed the definition of MPNs."

Prof. Dr. Martin Griesshammer

MPNs World Health Organisation Classification

The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms includes the following myeloproliferative neoplasms (MPNs): 

  • chronic myeloid leukemia (CML), BCR-ABL1+
  •  chronic neutrophilic leukemia (CNL)
  • polycythaemia vera (PV)
  • primary myelofibrosis (PMF)
  • essential thrombocythemia (ET)
  • chronic eosinophilic leukemia not otherwise specified (NOS)
  • MPN, unclassifiable.

Source: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Daniel A. Arber, Attilio Orazi, Robert Hasserjian, Jürgen Thiele, Michael J. Borowitz, Michelle M. Le Beau, Clara D. Bloomfield, Mario Cazzola and James W. Vardiman. Blood 2016 127:2391-2405.

Dr. Jean Jacques Kiladjian Professor of Clinical Hematology, Hospital Saint-Louis

"Under the umbrella of myeloproliferative neoplasms (MPNs) there are different diseases that belong to the family of malignancies. MPNs are completely different from solid cancers since MPNs are chronic diseases mostly. MPNs develop in the bone marrow of the patients and produce too many blood cells. According to the category of blood cells that are predominant, we can classify these diseases in different categories.

One is polycythaemia vera, there is mostly an increase of red blood cells but sometimes also along with too many white cells and platelets.

Then, if only platelets are increased, it’s usually essential thrombocythemia.

And you have the third one which is primary myelofibrosis that is a kind of a more heterogeneous disease group of patients with different aspects.

In general it’s always an overproduction of blood cells. “ 

What is PV and ET?

Click on the arrow icon below to find out more about Polycythaemia Vera and Essential Thrombocythemia, its causes, symptoms, and diagnosis.