At AOP Orphan, we have been contributing to research on myeloproliferative neoplasms (MPNs), the development of new treatments, its production and supply for many years. On September 12th – the 7th Annual MPN Awareness Day – we especially want to help towards raising awareness of MPNs, since we believe that informing, connecting and advocating for those who are affected and involved is crucial for the wellbeing of patients. We will extend these efforts over the following months and bring into focus relevant information, advice and insights on all our communication platforms.
“MPNs is a chronic haematological disease group caused by a stem-cell disorder. Dameshek was a haematologist who described sixty years ago in the United States this group of diseases. He was looking at common symptoms and phenomena e.g. thromboses, constitutional symptoms, but also the unifying hyper proliferation and the bone marrow combined with spinal megaly that increased event of thrombosis and bleeding. 2016 WHO has renewed the definition of MPNs"
Prof. Dr. Martin Griesshammer
The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms includes the following myeloproliferative neoplasms (MPNs):
Source: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Daniel A. Arber, Attilio Orazi, Robert Hasserjian, Jürgen Thiele, Michael J. Borowitz, Michelle M. Le Beau, Clara D. Bloomfield, Mario Cazzola and James W. Vardiman. Blood 2016 127:2391-2405.
Under the umbrella of myeloproliferative neoplasms (MPNs) there are diﬀerent diseases that belong to the family of malignancies. But it is completely diﬀerent from a solid cancer since MPNs are chronic diseases mostly. But still it is in that family of malignant cell, that develop in the bone marrow of the patients and produce too many blood cells. According to the category of blood cells that are predominant, we can classify these diseases in diﬀerent categories.
One is Polycythemia Vera, there is mostly an increase of red blood cells but sometimes also along with too many white cells and platelets. Then it’s usually Essential Thrombocythemia, and you have the third one which is Primary Myelofibrosis that is a kind of more heterogeneous disease group of patients with diﬀerent aspects. But mostly it’s always an overproduction of blood cells.“
Click on the arrow icon below to find out more about Polycythaemia Vera and Essential Thrombocythemia, its causes, symptoms, and diagnosis.